Bradley R. Kraemer, Ph.D. Assistant Professor Contact 301 Sparkman DriveShelby CenterRoom 369PHuntsville, AL 35899 Campus Map 256.824.6272bradley.kraemer@uah.edu Biography Research in the Kraemer lab focuses on the relationship between neurotrophin signaling and neurodegenerative diseases. Our recent research efforts revealed a novel mechanism through which the p75 neurotrophin receptor (p75NTR) is activated in dopaminergic neurons subjected to oxidative stress. A current aim of our research is to understand the role of this receptor signaling mechanism in neurodegeneration associated with Parkinson’s disease. Our laboratory is also interested in factors that regulate neurite degeneration, a cellular process associated with the early stages of multiple neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. We recently developed an automated method for measuring neurite degeneration in 2d cell culture systems, and we are currently utilizing this novel tool to investigate factors that regulate neurite degeneration progression. The Kraemer laboratory regularly provides training opportunities through which students learn to perform a range of molecular biology research methods using samples from cell culture and rodent models. We welcome inquiries from undergraduate students, M.S. students in the Biological Sciences program, and Ph.D. students in the Biotechnology program. We also value opportunities for collaboration. More information can be found at the personal website for the laboratory. Curriculum Vitae Research Website Education Postdoctoral Fellow, Vanderbilt University: 2014 – 2016 Certificate in College Teaching, Vanderbilt University: 2015 Ph.D. in Neuroscience, Vanderbilt University: 2014 B.S. in Neuroscience, Centenary College of Louisiana: 2008 Expertise Neurodegenerative Diseases Neurotrophin Signaling Oxidative Stress Molecular Biology Research Techniques Neuronal cell culture Quantification of protein and RNA abundance and localization Stereotaxic surgeries involving rodents Confocal microscopy Quantification of neurite degeneration in 2d culture systems Recent Publications Clements RT#*, Fuller LE#*, Kraemer KR, Radomski SA*, Hunter-Chang S, Hall WC*, Kalantar AA*, and Kraemer BR (2022). “Quantification of Neurite Degeneration with Enhanced Accuracy and Efficiency in an in vitro Model of Parkinson’s disease, eNeuro. 9 (2) ENEURO.0327-21.2022; DOI: https://doi.org/10.1523/ENEURO.0327-21.2022 Kraemer BR and Carter BD. (2021) Neurotrophin Receptor Signaling. In: Jez J. et el. (Eds). Encyclopedia of Biological Chemistry (Third Edition), Volume 6, (pp.187-200). Cambridge, MA: Elsevier. https://doi.org/10.1016/B978-0-12-819460-7.00310-8 Kraemer BR, Clements RT*, Escobedo CM, Nelson KS*, Waugh CD*, Elliott AS*, Hall WC*, and Schemanski MT* (2021) “c-Jun N-terminal Kinase Mediates Ligand-independent p75NTR Signaling in Mesencephalic Cells Subjected to Oxidative Stress” Neuroscience. 453:222-236. doi:10.1016/j.neuroscience.2020.11.036. Mobley BC, Kwon M, Kraemer BR, Hickman FE, Qiao J, Chung DH, Carter BD (2015). “Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis.” PLoS One. 10(7):e0133897. Kraemer BR, Snow JP*, Vollbrecht PJ, Pathak A, Valentine WM, Deutch AY, and Carter BD (2014). “A Role for the p75 Neurotrophin Receptor in Axonal Degeneration and Apoptosis Induced by Oxidative Stress” Journal of Biological Chemistry, 289(31):21205-16. Kraemer BR, Yoon SO, and Carter BD (2014). “The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor”. in Neurotrophic Factors, Handbook of Experimental Pharmacology (Book 220, Carter BD and Lewin GR, ed.), Springer. pp 121-164
